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Global Vascular Co., Ltd. hereby announces that our registered head office has been relocated to the address. New Head Office Address Mirio Jimbocho 11th Floor, 1-28-1 Kanda-Jimbocho, Chiyoda-ku, Tokyo 101-0051, Japan Former Head Office Address Ichigaya Science and Technology Innovation Center Building 2nd Floor, 3-8 Ichigayatamachi, Shinjuku-ku, Tokyo 162-0843, Japan With this relocation of our registered head office, we will continue to advance our research and development to deliver new treatment options in areas of high medical need. We sincerely appreciate your continued support.