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Global Vascular Co., Ltd. is pleased to announce the appointment of Ryutaro Iwanami as External Auditor, effective June 17, 2025. His appointment will further support our efforts to enhance corporate value and reinforce governance as we pursue our mission of "delivering the latest treatments to patients as quickly as possible." Career & Professional Experience  Passed the CPA exam and joined a major audit firm, working primarily on audits and advisory services for globally expanding financial institutions Assigned to the firm’s New York office (2007–2008)  Upon returning to Japan, served as Senior Manager, leading domestic and international audit teams Led audit teams as Executive Officer at a venture company, overseeing both internal audit operations and cross-functional collaboration  Established Iwanami CPA Office in 2015, serving as Representative  Founded Iplus Advisory Co., Ltd. in 2016, serving as President & CEO  Currently engaged in advisory services in financial accounting, managerial accounting, and business management  Qualifications   Certified Public Accountant Licensed Tax Accountant

The 31st annual meeting of the Japanese Society of Endovascular Intervention, chaired by our company’s director, Professor Hasebe, will take place at the Okinawa Convention Center from June 13 to 14, 2025. In addition to symposiums, presentations and live operation courses, this academic conference will also feature a pitch event that brings startup companies together with current investors and capitalists. Global Vascular will be exhibiting as one of the startups. Dates: June 13 - 14, 2025. Registration period: March 3 - June 14, 2025 Venue: Okinawa Convention Center (4-3-1 Mashiki, Ginowan City, Okinawa Prefecture) Chairman: Professor Terumitsu Hasebe (Department of Diagnostic Radiology/ Endovascular Intervention Center, Tokai University Hachioji Hospital) For further details, please see the annual meeting website below. https://n-practice.co.jp/JSEI2025/index.html

On February 14 ,2025, Ms. Naoko Ishihara was appointed as an outside auditor of our company. As an attorney-at-law, Ms. Ishihara has extensive experience and a proven track record in a wide range of fields, including intellectual property, M&A, startup support, venture capital investment, corporate law including intellectual property strategy and strategic business alliances, cross-border transactions, and dispute resolution. With Ms. Ishihara's appointment, the company will work to further improve its corporate value and strengthen its governance structure in order to achieve its mission of "delivering the latest treatments to patients as quickly as possible." We would like to thank you for your continued support in the future.

Dr. Matsuoka and Dr. Hasebe will be speaking at TCT 2024, the world's largest cardiovascular congress to be held October 27-30, 2024 (Washington, DC local time), to present the latest data on the stent delivery system under development. Sunday, October 27, 9:00 – 10:00AM Moderated Abstracts, Critical Limb Threatening Ischemia - 1 Pre-Clinical Data on a Novel Hybrid Drug-Eluting Stent with Nanocoating for Below-the-Knee Lesions: “Leave the Right Thing Behind” / Emi Matsuoka Kearon Wednesday, October 30, 11:00 – 11:30AM Moderated Abstracts, Peripheral Arterial and Venous Disease and Intervention - 4 The Novel Hybrid Nano-coating Ni-Ti stent for below-the-knee atherosclerotic disease: The Newest “Leave the Right Thing Behind” Concept / Terumitsu Hasebe https://tct2024.crfconferences.com/

Emi Matsuoka, COO of Global vascular was invited to speak at the first “Ph.D. Career Talk Series” event held by Blockbuster TOKYO, a program launched in fiscal 2018 by the Tokyo Metropolitan Government to support the development of drug discovery and medical startups in order to realize “Tokyo, the world's number one startup city. https://www.link-j.org/bbt/event/post-8702.html

Dr. Hasebe, took the stage at EuroPCR2024 and PCR Innovators Day, the world's leading academic conference in the field of catheterization in cardiovascular diseases, held from May 13 to 17, 2024 (Paris local time), to present the latest data on the stent delivery system under development. The latest data of the stent delivery system under development was presented. May 13, Monday CEST　 E-Posters - PCR Innovator's Day 2024 update on the impact of a hybrid nano-coated nitinol drug-eluting stent (hybrid-DES) for BTK / Terumitsu Hasebe May 15, Wednesday /  14:45 – 16:15 CEST　 Innovations for lower limb revascularisation Moderators: Piotr Musialek/Parham Sadeghipour Hybrid nano-coated nitinol drug-eluting stent (Hybrid-DES) and its impact on below the knee / Terumitsu Hasebe https://www.pcronline.com/Courses/EuroPCR

On May 29, 2024, at 14:40 (local time in Germany), Dr. Hasebe will be speaking at LINC 2024, the world's leading conference in the field of Interventional Radiology, to present the latest data on the stent delivery system currently under development. May 29, Wednesday / 14:30 – 15:30 CEST　SPEAKERS CORNER UPDATE ON LATEST DATA AND ONGOING TRIALS: NEW TECHNOLOGIES FOR CLTI/BTK TREATMENT Moderators: Marianne Brodmann/Francesco Liistro Impact of a hybrid nano-coated ultrathin nitinol drug-eluting stent (Hybrid-DES) for below-the-knee atherosclerotic disease: 2024 update / Terumitsu Hasebe https://www.leipzig-interventional-course.com/

On May 1, 2024 (U.S. West Coast Standard Time), our company, Maekawa, Hasebe, and Matsuoka spoke at the MedTech Innovator pitch event, the largest MedTech accelerator program in the United States. We were one of only 200 Japanese companies selected from more than 1,400 applicants.

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